Metallothionein Response
Gene co-expression module in Colorectal carcinoma
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 6 of 12 genes have a known function matching the annotation |
Why this annotation
Four metallothionein genes (MT1M, MT2A, MT1E, MT1X, MT1G) dominate this module with top PageRank scores. Metallothioneins are small cysteine-rich proteins induced by heavy metals, oxidative stress, and inflammatory cytokines; they are frequently dysregulated in CRC. CRIP1 is a LIM-domain zinc-binding protein co-regulated with metallothioneins. CFD (complement factor D) and METRN add peripheral signals. The strong-coherent module with MT gene dominance unambiguously reflects a metallothionein/metal-stress response program in colon epithelial cells.
Genes
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.