IGF2 Growth Signaling
Gene co-expression module in Colorectal carcinoma
| Category | GF response |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 10 genes have a known function matching the annotation |
Why this annotation
IGF2 is the dominant hub and is a well-characterized imprinted growth factor frequently overexpressed in CRC through loss of imprinting. TGFBI is a TGF-beta-induced extracellular matrix protein involved in cell adhesion and invasion. PHLDA1 is induced by growth factor and stress signaling. HSPA1A is a heat-shock chaperone reflecting stress-associated growth factor responses. SMOC2 is a matricellular protein linked to Wnt/growth factor signaling. TESC is a calcium-binding protein. The module is moderate coherence and somewhat mixed, but IGF2-centered growth factor signaling is the dominant theme, consistent with a CRC-relevant paracrine/autocrine growth program.
Genes
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.