LOXL1 — Lysyl oxidase like 1
LOXL1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LOXL1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Stromal Fibroblast Activation ECM remodeling | DDR2, FMOD, HSD11B1, METRNL, PRRX2, PRSS23, TWIST2 | View in SCUBA |
About the gene
| Synonyms | LOL, LOXL |
|---|---|
| Chromosome | 15: 73925989-73952137 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Plasma proteins, Predicted secreted proteins |
| Molecular function | Oxidoreductase |
Function
Catalyzes the oxidative deamination of lysine and hydroxylysine residues in collagen and elastin, resulting in the formation of covalent cross-linkages, and the stabilization of collagen and elastin fibers (By similarity). Essential for the elastic fiber homeostasis and for their maintenance at adult age (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.