NR2C1 — Nuclear receptor subfamily 2 group C member 1
NR2C1 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NR2C1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Stem Cell Epigenetic chromatin regulation & transcription | ATAT1, CEP295, CNTN3, DNMT3A, EARS2, FYB2, KAT2A, LONRF1 +16 more | View in SCUBA |
About the gene
| Synonyms | TR2, TR2-11 |
|---|---|
| Chromosome | 12: 95020229-95073628 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Nuclear receptors, Plasma proteins, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding, Receptor, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.