Stem Cell Epigenetic
Gene co-expression module in Colonocytes
| Category | chromatin regulation & transcription |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 25 genes have a known function matching the annotation |
Why this annotation
Very low mean expression (0.043) and detection (6.5%), with multiple genes 'not detected' in any subset. Hub genes include EARS2 and TARS2 (mitochondrial aminoacyl-tRNA synthetases), LRIG1 (intestinal stem cell/crypt marker, 2.7x crypt enrichment), DNMT3A (de novo DNA methylation), SETD6 (lysine methyltransferase), CNTN3 (contactin, neural/rare cell), NMB (neuromedin B, enteroendocrine), TGIF2 (TGF-beta signaling). The combination of very low detection, 'not detected' genes, LRIG1 crypt enrichment, and DNMT3A/SETD6 chromatin regulators suggests this module captures a rare stem/progenitor cell epigenetic state. The mitochondrial tRNA synthetases may reflect metabolic demands of stem cells.
Genes
Most correlated modules
- Ribosome Biogenesis · correlation 0.96
- Vesicular Trafficking · correlation 0.94
- Cellular Senescence · correlation 0.83
- Mitochondrial Maintenance · correlation 0.81
- Ubiquitin-Proteasome System · correlation 0.81
- BEST4 Colonocyte Identity · correlation 0.75
- RNA Splicing Regulation · correlation 0.74
- Metabolic Homeostasis · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.