POMGNT1 — Protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)
POMGNT1 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
POMGNT1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Stem Cell Epigenetic chromatin regulation & transcription | ATAT1, CEP295, CNTN3, DNMT3A, EARS2, FYB2, KAT2A, LONRF1 +16 more | View in SCUBA |
About the gene
| Synonyms | FLJ20277, LGMD2O, MEB, MGAT1.2 |
|---|---|
| Chromosome | 1: 46188683-46220305 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Metabolic proteins, Predicted membrane proteins |
| Molecular function | Glycosyltransferase, Transferase |
Function
Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha- dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose and does not have MGAT3, MGAT4, MGAT5, MGAT7 or MGAT8 activity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.