TARS2 — Threonyl-tRNA synthetase 2, mitochondrial
TARS2 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TARS2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Stem Cell Epigenetic chromatin regulation & transcription | ATAT1, CEP295, CNTN3, DNMT3A, EARS2, FYB2, KAT2A, LONRF1 +16 more | View in SCUBA |
About the gene
| Synonyms | FLJ12528, TARSL1 |
|---|---|
| Chromosome | 1: 150487414-150507602 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Aminoacyl-tRNA synthetase, Ligase |
| Biological process | Protein biosynthesis |
Function
Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.