TRIM52 — Tripartite motif containing 52
TRIM52 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TRIM52's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Transcription-Coupled Splicing RNA processing & translation | ANKRD26, ANKRD36, ANKS3, C1orf35, CDK10, CDK12, CHD6, CWF19L2 +31 more | View in SCUBA |
About the gene
| Synonyms | RNF102 |
|---|---|
| Chromosome | 5: 181254077-181261150 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Transferase |
| Biological process | Antiviral defense, Ubl conjugation pathway |
Function
E3 ubiquitin-protein ligase. Positively regulates the NF-kappa-B signaling pathway. (Microbial infection) Exhibits antiviral activity against Japanese encephalitis virus (JEV). Ubiquitinates the viral non- structural protein 2 (NS2A) and targets it for proteasome-mediated degradation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.