T-cell activation
Gene co-expression module in CD4⁺ T cells
| Category | TCR/AP1/NFKb pathway |
|---|---|
| Genes | 16 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes are functionally diverse: SNX9 (endocytosis), CD4/CD7 (T-cell markers), CDK6 (cell cycle), CBLB (T-cell anergy/tolerance E3 ligase), HDAC7, CAMK1. The module is uniformly expressed at low levels with no dominant subset, and combines TCR-tolerance regulators (CBLB, HDAC7), T-cell identity markers (CD4, CD7), and housekeeping/trafficking genes. The strong inflammation correlation and presence of CD4/CD7/CBLB suggest a general CD4 T-cell activation/identity state rather than a single tight program. Weak signal toward a definable pathway; CD4/CD7/CBLB anchor it as T-cell activation/regulation.
Genes
C16orf87, CAMK1, CBLB, CD4, CD7, CDK6, CIAO1, COPB2, DGUOK, DNAJA2, F5, GPRIN3, HDAC7, ITPR1, PPP4R2, SNX9
Most correlated modules
- Proteasome/translation · correlation 0.89
- RNA processing splicing · correlation 0.88
- NF-kB regulation · correlation 0.87
- Cellular biosynthesis · correlation 0.87
- Proteostasis OxPhos · correlation 0.86
- Membrane trafficking · correlation 0.85
- MAF regulatory program · correlation 0.83
- mRNA stability regulation · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.