CD4⁺ T cells: gene co-expression modules
Helper T lymphocytes recognising peptide on MHC class II; differentiate into Th1, Th17, Tfh, or regulatory subsets that orchestrate antibody production, phagocyte activation, and mucosal tolerance.
SCUBA's reference network for CD4⁺ T cells holds 149 gene modules covering 2,742 genes. Each module is a group of genes that rise and fall together across these cells, annotated with the biological process it most likely represents.
View the CD4⁺ T cells network in SCUBA
Anti-viral (5)
- Activated Effector ISG · 17 genes
- Interferon response · 16 genes
- Interferon response · 32 genes
- Interferon Response · 13 genes
- Interferon-stimulated genes · 23 genes
B cell help (4)
- T Cell Signaling · 13 genes
- Tfh CXCL13 program · 14 genes
- Tfh IL21 help · 15 genes
- Tfh program · 19 genes
Cell contamination (1)
- Gamma-delta T cell · 18 genes
Cell cycle (1)
- Proliferation/differentiation · 8 genes
Cytoskeletal (3)
- Actin Cytoskeleton · 15 genes
- Actin cytoskeleton · 12 genes
- Cytoskeleton & metabolism · 20 genes
Cytotoxicity (4)
- Cytotoxic effector · 20 genes
- Cytotoxic effector · 24 genes
- Cytotoxic effector · 19 genes
- Cytotoxic Effector CD4 · 22 genes
DNA/chromatin regulation (10)
- Cell cycle regulators · 8 genes
- Chromatin Regulation · 26 genes
- Chromatin regulation · 21 genes
- Chromatin transcription regulation · 19 genes
- DNA damage response · 16 genes
- DNA repair/replication · 13 genes
- Epigenetic regulation · 15 genes
- Pol II Transcription Regulation · 37 genes
- Transcriptional regulation · 17 genes
- TRIM28-ZNF Repression · 16 genes
Exhaustion (1)
- T cell exhaustion · 12 genes
Housekeeping (13)
- Cellular biosynthesis · 18 genes
- Lipid Metabolism · 12 genes
- Membrane trafficking · 28 genes
- Metabolic reprogramming · 21 genes
- Nucleotide biosynthesis · 15 genes
- Proteasome translation · 14 genes
- Proteostasis OxPhos · 15 genes
- Ribosomal proteins · 8 genes
- Ribosome biogenesis · 26 genes
- Translation machinery · 11 genes
- Vesicle trafficking · 30 genes
- Vesicle Trafficking Signaling · 30 genes
- Vesicular trafficking · 26 genes
Immune regulation (30)
- Activated effector Tcell · 13 genes
- Activated Treg · 15 genes
- Activated Treg · 22 genes
- CD200 immunoregulation · 32 genes
- Cytokine receptor signaling · 10 genes
- Cytokine signaling · 21 genes
- Effector Immune Activation · 16 genes
- GIMAP survival · 25 genes
- Glucocorticoid Immunoregulation · 20 genes
- IL10/cytokine signaling · 13 genes
- Immune Regulation · 19 genes
- Immune regulation · 14 genes
- Inflammatory activation · 16 genes
- Inflammatory activation · 19 genes
- Inflammatory effector · 18 genes
- JAK-STAT Signaling · 16 genes
- LAYN+ tissue Treg · 16 genes
- MAF regulatory program · 21 genes
- MHC-II antigen presentation · 12 genes
- mRNA stability regulation · 21 genes
- PD-L1 checkpoint · 22 genes
- Regulatory T cell · 15 genes
- Regulatory T cell · 16 genes
- Resting memory T cell · 14 genes
- T cell Coinhibition · 16 genes
- T cell quiescence · 12 genes
- T-cell quiescence regulation · 13 genes
- Th1 IL12 response · 11 genes
- TNF activation survival · 21 genes
- Treg regulation · 17 genes
Intercellular communication (2)
- IL6-STAT3 Signaling · 22 genes
- TGF-beta response · 12 genes
migration & adhesion (10)
- Actomyosin signaling · 17 genes
- CCR5 effector migration · 19 genes
- Cell motility/adhesion · 23 genes
- Chemokine Migration · 16 genes
- Integrin adhesion · 13 genes
- Integrin Adhesion Migration · 20 genes
- Integrin Rap1 Signaling · 17 genes
- Leukocyte adhesion signaling · 31 genes
- Leukocyte Motility · 10 genes
- Rho-GTPase Migration · 13 genes
Mitochondrial & OxPhos (10)
- Mitochondrial OxPhos · 28 genes
- Mitochondrial Translation · 26 genes
- Oxidative Phosphorylation · 19 genes
- Oxidative Phosphorylation · 15 genes
- Oxidative phosphorylation · 21 genes
- Oxidative Phosphorylation · 19 genes
- Oxidative Phosphorylation · 28 genes
- OxPhos & proteasome · 19 genes
- OxPhos & redox · 14 genes
- Respiratory chain assembly · 9 genes
Protein processing & ER (9)
- Chaperone Proteostasis · 16 genes
- ER protein processing · 8 genes
- ER stress UPR · 18 genes
- ER-Golgi Trafficking · 13 genes
- Glycosylation & trafficking · 34 genes
- Membrane Trafficking · 32 genes
- Proteasome/translation · 18 genes
- Protein/ER secretory machinery · 25 genes
- Unfolded Protein Response · 16 genes
RNA processing (9)
- mRNA Processing · 18 genes
- mRNA splicing · 17 genes
- mRNA Splicing Factors · 17 genes
- mRNA Splicing Processing · 16 genes
- Post-transcriptional regulation · 30 genes
- RNA & Chromatin Regulation · 16 genes
- RNA processing · 16 genes
- RNA processing splicing · 20 genes
- Transcription/RNA processing · 38 genes
Stress (5)
- Heat Shock Response · 21 genes
- Heat-shock response · 14 genes
- Hypoxia metabolic stress · 22 genes
- Integrated Stress Response · 9 genes
- p53 DNA-damage response · 9 genes
T cell development (7)
- CD4 Lineage Identity · 15 genes
- Naive resting T cell · 16 genes
- Naive T cell · 30 genes
- Naive T cell · 18 genes
- Naive T quiescence · 15 genes
- T cell co-receptors · 22 genes
- T cell signaling · 8 genes
TCR/AP1/NFKb pathway (21)
- AKT survival signaling · 19 genes
- Effector activation NFkB · 32 genes
- Immediate early activation · 27 genes
- Immediate Early AP-1 · 15 genes
- MAPK feedback signaling · 11 genes
- NF-kB activation · 18 genes
- NF-kB activation · 30 genes
- NF-kB feedback · 17 genes
- NF-kB Feedback Response · 11 genes
- NF-kB regulation · 18 genes
- NFAT activation · 22 genes
- T cell activation · 12 genes
- T-cell activation · 16 genes
- T-cell costimulation · 19 genes
- TCR Activation Signaling · 15 genes
- TCR Complex Activation · 23 genes
- TCR early activation · 20 genes
- TCR signaling · 28 genes
- TCR signaling · 24 genes
- TCR signaling activation · 17 genes
- TNF/NF-kB activation · 15 genes
Technical artifact (1)
- Mixed Metabolic Ambient · 10 genes
Th17 fate (3)
- Th17 effector · 15 genes
- Th17 lineage · 22 genes
- Th17/MAIT type-17 · 18 genes