Epithelial Oxidative Stress
Gene co-expression module in Colorectal carcinoma
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 14 genes have a known function matching the annotation |
Why this annotation
DUOX2 and DUOXA2 form the dual oxidase complex that generates reactive oxygen species at the intestinal epithelial surface, induced under inflammatory and stress conditions. GPX2 encodes a glutathione peroxidase that counteracts ROS in intestinal epithelium. ID1 is a BMP-responsive inhibitor of differentiation expressed in intestinal crypts. FABP1 marks enterocyte/colonocyte lineage. KRT20 and PHGR1 are colonocyte markers. SPINK1 is a protease inhibitor upregulated in intestinal epithelial stress and CRC. CEMIP is associated with epithelial remodeling. The DUOX2/DUOXA2/GPX2 axis, with moderate coherence, points to an intestinal epithelial oxidative/ROS stress response program.
Genes
Most correlated modules
- Colonocyte Differentiation · correlation 0.58
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.