Colonocyte Differentiation
Gene co-expression module in Colorectal carcinoma
| Category | Dedifferentiation & EMT |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 20 genes have a known function matching the annotation |
Why this annotation
CDX2 is the master transcription factor for colonocyte identity. SELENBP1 is a well-established colonocyte differentiation marker frequently lost in CRC. SLC26A3 (DRA) is a chloride/bicarbonate exchanger specific to colonocytes. DPEP1 is a brush-border enzyme. HMGCS2 is a colonocyte-enriched ketogenic enzyme. UGT2B17 and QPRT reflect colonocyte-specific metabolic programs. ASCL2 is an intestinal stem/progenitor TF. CA12 is expressed in differentiated colon epithelium. PTPRO and GPR160 are colon epithelial markers. Collectively this module defines a colonocyte differentiation/colonic epithelial identity program.
Genes
Most correlated modules
- Ceramide Lipid Metabolism · correlation 0.61
- Golgi-Nuclear Organization · correlation 0.59
- Epithelial Oxidative Stress · correlation 0.58
- WNT Stem Cell · correlation 0.56
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.