OxPhos & Translation
Gene co-expression module in Dendritic cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 16 of 20 genes have a known function matching the annotation |
Why this annotation
The module is strongly coherent with high mean expression and detection rate, consistent with housekeeping activity. COX4I1, COX7C (cytochrome c oxidase subunits IV and VIIc), UQCRB, UQCR11 (Complex III subunits), ATP5MC2, ATP5F1E (ATP synthase subunits), SLC25A6 (adenine nucleotide translocator 3), and TOMM7 (TOM complex) are all mitochondrial OxPhos/import components. EEF1B2 (translation elongation factor), EIF3H, EIF3E, EIF3F (eIF3 subunits), NACA (nascent polypeptide-associated complex alpha), BTF3 (beta-transcription factor 3, ribosome-associated), and RACK1 (ribosome scaffold) are translation machinery. PFDN5 is a prefoldin chaperone for nascent proteins. The co-expression of OxPhos and translation components is a classic housekeeping signature reflecting coupled energy production and protein synthesis. Neighbor M131 also contains mitochondrial assembly genes, reinforcing the mitochondrial theme in this neighborhood.
Genes
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.