Dendritic cells: gene co-expression modules

Professional antigen-presenting sentinels sampling the lumen and lamina propria; on activation they migrate to lymph nodes and prime naive T cells, setting immunity or tolerance.

SCUBA's reference network for Dendritic cells holds 154 gene modules covering 3,517 genes. Each module is a group of genes that rise and fall together across these cells, annotated with the biological process it most likely represents.

View the Dendritic cells network in SCUBA

Ag processing & presentation (7)

• CD1 Lipid Presentation · 0 genes
• DC Migratory Antigen Processing · 0 genes
• ER Protein Folding · 0 genes
• ER Translocon Processing · 0 genes
• MHC-I Antigen Presentation · 0 genes
• MHC-II Presentation · 0 genes
• Phagosomal Antigen Processing · 0 genes

Cross-presentation (1)

• cDC1 Cross-Presentation · 0 genes

Cytoskeletal (8)

• Actin Cytoskeletal Remodeling · 0 genes
• Actin Cytoskeleton Remodeling · 0 genes
• Actin Polymerization · 0 genes
• Actomyosin Cytoskeletal · 0 genes
• Cytoskeletal Motor Activity · 0 genes
• DC Actin Migration · 0 genes
• Focal Adhesion Remodeling · 0 genes
• Phagocytic Cytoskeletal · 0 genes

Development (10)

• cDC1 Epigenetic Regulation · 0 genes
• cDC1 Identity · 0 genes
• cDC1 Transcription Factors · 0 genes
• cDC2 Identity · 0 genes
• cDC2 Identity · 0 genes
• cDC2 Identity · 0 genes
• cDC2 Identity · 0 genes
• DC Differentiation Migration · 0 genes
• DC Maturation State · 0 genes
• Immature DC Metabolism · 0 genes

Housekeeping (26)

• Alternative Splicing · 0 genes
• Chromatin Remodeling · 0 genes
• Chromatin Remodeling · 0 genes
• Epigenetic Regulation · 0 genes
• ER Protein Biogenesis · 0 genes
• ER Protein Processing · 0 genes
• Genome Maintenance · 0 genes
• hnRNP Splicing Program · 0 genes
• Metabolic Housekeeping · 0 genes
• Metabolic Housekeeping · 0 genes
• Metabolic Housekeeping · 0 genes
• mRNA Processing & Translation · 0 genes
• mRNA Splicing · 0 genes
• Myeloid DC Identity · 0 genes
• p53 Transcriptional Regulation · 0 genes
• Proliferating DC Housekeeping · 0 genes
• Proteasome & Glycolysis · 0 genes
• Proteostasis & Chaperones · 0 genes
• Ribosome Biogenesis · 0 genes
• Ribosome Biogenesis · 0 genes
• RNA Splicing Processing · 0 genes
• RNA Splicing Processing · 0 genes
• RNA Splicing Processing · 0 genes
• Sterol Biosynthesis cDC1 · 0 genes
• Telomere Maintenance · 0 genes
• Transcriptional Homeostasis · 0 genes

Inflammatory (18)

• Acute Inflammatory Activation · 0 genes
• Acute NF-κB Response · 0 genes
• AP-1 cDC2 Activation · 0 genes
• cDC1 NFAT Signaling · 0 genes
• Cytokine Receptor Signaling · 0 genes
• Cytokine-responsive mDC · 0 genes
• Death Receptor Signaling · 0 genes
• Inflammatory Stress Response · 0 genes
• Innate Myeloid Sensing · 0 genes
• JAK-STAT Cytokine Signaling · 0 genes
• Leukotriene IL-18 Signaling · 0 genes
• mDC Inflammatory Activation · 0 genes
• MMP9 Effector cDC2 · 0 genes
• NF-κB DC Activation · 0 genes
• Non-canonical NF-κB · 0 genes
• OLR1+ cDC2 Subset · 0 genes
• TNF/NF-κB DC Activation · 0 genes
• Type I Interferon · 0 genes

Lysosomal & pahgocytosis (8)

• Endosomal DC Program · 0 genes
• Endosomal DC Trafficking · 0 genes
• IFNγ-primed Phagocytosis · 0 genes
• Lysosomal Antigen Processing · 0 genes
• Lysosomal AP-3 Trafficking · 0 genes
• Lysosomal Lipid Catabolism · 0 genes
• Lysosomal Trafficking Regulation · 0 genes
• Lysosomal Vesicular Trafficking · 0 genes

Migration & adhesion (4)

• DC Maturation Migration · 0 genes
• DC Metabolic Activation · 0 genes
• Gut-Homing DC · 0 genes
• Integrin Adhesion Signaling · 0 genes

Mitochondrial & OxPhos (10)

• Complex I Assembly · 0 genes
• Mitochondrial Biogenesis · 0 genes
• Mitochondrial DNA Repair · 0 genes
• Mitochondrial Metabolism UCP2 · 0 genes
• Mitochondrial OxPhos · 0 genes
• Mitochondrial OxPhos · 0 genes
• Mitochondrial Ribosome · 0 genes
• Mitochondrial Ribosome Biogenesis · 0 genes
• Oxidative Phosphorylation · 0 genes
• OxPhos & Translation · 0 genes

Pathogen response (5)

• cDC2 CLR Signaling · 0 genes
• IFN-gamma Response · 0 genes
• Monocyte-derived cDC2 · 0 genes
• TLR-MYD88 Signaling · 0 genes
• Type I Interferon · 0 genes

Proliferation (23)

• Cell Cycle Checkpoint · 0 genes
• Chromatin Remodeling · 0 genes
• DC Proliferation · 0 genes
• DC Proliferation Program · 0 genes
• DC Proliferation Program · 0 genes
• DNA Damage Response · 0 genes
• DNA Replication Chromatin · 0 genes
• DNA Replication Support · 0 genes
• G1/S Cell Cycle · 0 genes
• G2/M Checkpoint · 0 genes
• Mitotic Nuclear Envelope · 0 genes
• Mitotic Proliferation · 0 genes
• Mitotic Spindle · 0 genes
• Mitotic Spindle · 0 genes
• MYC-driven Proliferation · 0 genes
• Nucleotide Biosynthesis · 0 genes
• Proliferating DC Mixed · 0 genes
• Proliferating DC Program · 0 genes
• Proliferating DC State · 0 genes
• Replication Licensing · 0 genes
• RNA Processing Proliferation · 0 genes
• S-phase Replication · 0 genes
• Spliceosome RNA Processing · 0 genes

Stress (11)

• DNA Damage Repair · 0 genes
• ER Proteostasis Stress · 0 genes
• Glucocorticoid Stress Response · 0 genes
• Heat Shock Response · 0 genes
• Immediate Early Response · 0 genes
• Mitochondrial Stress Assembly · 0 genes
• Myeloid Autophagy Stress · 0 genes
• Myeloid Stress Response · 0 genes
• NRF2 Metabolic Stress · 0 genes
• Oxidative Stress Response · 0 genes
• Unfolded Protein Response · 0 genes

Tolerance (10)

• mDC Tolerogenic Identity · 0 genes
• Myeloid Inhibitory Receptors · 0 genes
• Regulatory mDC Activation · 0 genes
• TGF-beta Response · 0 genes
• Tolerogenic cDC2 State · 0 genes
• Tolerogenic DC Signaling · 0 genes
• Tolerogenic DC State · 0 genes
• Tolerogenic Lipid Metabolism · 0 genes
• Tolerogenic mDC · 0 genes
• Tolerogenic mDC Activation · 0 genes

Vesicular traficking (13)

• Endocytic Vesicular Trafficking · 0 genes
• Endosomal Retromer Trafficking · 0 genes
• Endosomal Trafficking · 0 genes
• Endosomal Trafficking · 0 genes
• Endosomal Vesicle Trafficking · 0 genes
• ER Membrane Biogenesis · 0 genes
• Golgi-Endosomal Trafficking · 0 genes
• Golgi-Lysosome Trafficking · 0 genes
• Lysosomal Vesicle Trafficking · 0 genes
• mDC Vesicular Trafficking · 0 genes
• mTOR Nutrient Sensing · 0 genes
• SNARE Vesicular Trafficking · 0 genes
• Vesicular Housekeeping · 0 genes