Mitochondrial Ribosome
Gene co-expression module in Dendritic cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 12 genes have a known function matching the annotation |
Why this annotation
This module has moderate coherence and mixed membership scores. Hub genes: MRPL17 (mitochondrial ribosomal protein, large subunit), TMA16 (ribosome biogenesis), ANAPC5 (APC/C complex, cell cycle), NDUFA13 (NADH dehydrogenase, OxPhos), MRPL23/MRPL36 (mitochondrial ribosomal proteins), TXN2 (mitochondrial thioredoxin, redox), MIF (macrophage migration inhibitory factor, cytokine), SLIRP (mitochondrial RNA binding), RPIA (pentose phosphate pathway), PTOV1 (cell proliferation), TAF15 (transcription). The module combines mitochondrial ribosome (MRPL17, MRPL23, MRPL36, SLIRP) with cell cycle (ANAPC5, PTOV1) and OxPhos (NDUFA13, TXN2) genes. Given neighbor context (M3 is OxPhos, M129 is mitotic), this module sits at the intersection. The dominant hub genes are mitochondrial ribosomal proteins. This is a mitochondrial ribosome/translation module with mixed cell cycle contamination, consistent with moderate coherence.
Genes
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.