Heat Shock Response
Gene co-expression module in Dendritic cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 15 of 20 genes have a known function matching the annotation |
Why this annotation
The top hub genes are HSPA1B, HSPA1A, HSP90AA1, HSPE1, HSP90AB1, DNAJB1, HSPH1, HSPD1, DNAJA1, DNAJA4, AHSA1, HSPA8, CHORDC1, BAG3 — a canonical heat shock protein / proteostasis stress response module. This is a well-characterized stress response program induced by proteotoxic stress, heat, or dissociation during tissue processing. JUN co-expression links it to the AP-1/immediate-early response seen in M115, consistent with a shared stress activation context. The module decreases with treatment (delta_treatment_post_pre = -0.326), suggesting it may reflect disease-associated cellular stress. The neighbor M115 (immediate-early genes) strongly supports a dissociation/cellular stress interpretation for this neighborhood.
Genes
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.