Endolysosomal Trafficking
Gene co-expression module in Mast cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes SNX13 (sorting nexin, endosomal membrane tubulation), PEX1 (AAA-ATPase essential for peroxisome biogenesis/import), ABCA5 (ABC transporter, lysosomal cholesterol transport), TECPR2 (autophagy receptor linking autophagosomes to lysosomes), TBC1D19 (Rab GTPase-activating protein, endosomal trafficking), KLHL24 (ubiquitin ligase adaptor). The module is unified by vesicular trafficking and organelle biogenesis — particularly peroxisomal (PEX1) and endolysosomal (SNX13, TECPR2, TBC1D19, ABCA5) pathways. Low expression and pct positive suggest sparse expression. No significant disease associations.
Genes
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.