Mast cells: gene co-expression modules

Tissue-resident granulocytes derived from bone marrow progenitors, storing histamine and proteases; IgE crosslinking triggers rapid degranulation, driving allergy, parasite defence, and innate mucosal immune regulation.

SCUBA's reference network for Mast cells holds 189 gene modules covering 4,145 genes. Each module is a group of genes that rise and fall together across these cells, annotated with the biological process it most likely represents.

View the Mast cells network in SCUBA

Cell cycle (13)

• Centrosome Biogenesis · 0 genes
• Centrosome Biogenesis · 0 genes
• Chromatin Cell Cycle · 0 genes
• DNA Replication · 0 genes
• DNA Replication Repair · 0 genes
• FA DNA Repair · 0 genes
• G2/M Checkpoint · 0 genes
• Mitotic Spindle · 0 genes
• Mitotic Spindle · 0 genes
• Mitotic Spindle · 0 genes
• S-phase DNA Replication · 0 genes
• S-phase Histones · 0 genes
• S-phase Replication · 0 genes

Cytoskeletal (10)

• Actin Cytoskeletal Dynamics · 0 genes
• Actin Cytoskeleton Organization · 0 genes
• Actin Cytoskeleton Remodeling · 0 genes
• Cytoskeletal Organization · 0 genes
• Cytoskeletal Remodeling · 0 genes
• Cytoskeletal Signaling · 0 genes
• Cytoskeletal Trafficking · 0 genes
• mTOR-Cytoskeletal Regulation · 0 genes
• Phosphoinositide Cytoskeletal Signaling · 0 genes
• Rho GTPase Signaling · 0 genes

Degranulation (5)

• Autophagy & Lysosomal · 0 genes
• Endolysosomal Trafficking · 0 genes
• Mast Cell Degranulation · 0 genes
• Membrane Lipid Signaling · 0 genes
• Vesicle Trafficking Secretion · 0 genes

DNA/chromatin regulation (30)

• BRD4 Chromatin Regulation · 0 genes
• Chromatin & Ubiquitin Regulation · 0 genes
• Chromatin Epigenetic Regulation · 0 genes
• Chromatin Epigenetic Regulation · 0 genes
• Chromatin Remodeling · 0 genes
• Chromatin Remodeling · 0 genes
• Chromatin Transcriptional Regulation · 0 genes
• Circadian Clock Regulation · 0 genes
• Circadian Transcription · 0 genes
• DNA Damage Chromatin · 0 genes
• DNA Damage Repair · 0 genes
• DNA Damage Response · 0 genes
• DNA Damage Response · 0 genes
• DNA Damage Response · 0 genes
• Epigenetic Transcriptional Control · 0 genes
• Histone Methylation Regulation · 0 genes
• Histone Ubiquitination · 0 genes
• Histone Variant Chromatin · 0 genes
• ISG Regulatory Program · 0 genes
• LXR/PPAR Repression · 0 genes
• Mediator-Integrator Transcription · 0 genes
• Quiescence Epigenetic · 0 genes
• SMC Chromatin Maintenance · 0 genes
• SWI/SNF Remodeling · 0 genes
• Telomere Maintenance · 0 genes
• Transcriptional Regulation · 0 genes
• Transcriptional Regulation · 0 genes
• Transcriptional Regulation · 0 genes
• Ubiquitin-Chromatin Regulation · 0 genes
• Ubiquitin-Chromatin Regulation · 0 genes

Eicosanoid metabolism (2)

• Eicosanoid Biosynthesis · 0 genes
• Leukotriene Biosynthesis · 0 genes

Housekeeping (27)

• Aminoacyl-tRNA Synthetase · 0 genes
• Basal Mast Signaling · 0 genes
• Cellular Housekeeping Mixed · 0 genes
• Endolysosomal Trafficking · 0 genes
• Endosomal Trafficking · 0 genes
• Endosomal Vesicle Trafficking · 0 genes
• ER-Golgi Trafficking · 0 genes
• General Cellular Maintenance · 0 genes
• General Housekeeping · 0 genes
• General Housekeeping · 0 genes
• General Housekeeping · 0 genes
• Housekeeping Maintenance · 0 genes
• Housekeeping Signaling · 0 genes
• Intracellular Trafficking · 0 genes
• JAK-TEC Signaling · 0 genes
• Lipid-Metabolic Homeostasis · 0 genes
• Lysosomal Autophagy · 0 genes
• Mast Cell Homeostasis · 0 genes
• Mitochondrial Protein Import · 0 genes
• Mixed Housekeeping · 0 genes
• PI3K-Wnt Signaling · 0 genes
• Protein Biogenesis Housekeeping · 0 genes
• Protein Homeostasis · 0 genes
• RNA & Membrane Housekeeping · 0 genes
• RNA & Protein Homeostasis · 0 genes
• Transcriptional Metabolic Regulation · 0 genes
• Ubiquitin-Lysosomal Maintenance · 0 genes

Immune regulation (22)

• Calcium Store Signaling · 0 genes
• Calcium-GPCR Signaling · 0 genes
• Cytokine Receptor Signaling · 0 genes
• Immune Activation Signaling · 0 genes
• Immune Checkpoint State · 0 genes
• Innate Immune Regulation · 0 genes
• Innate Immune Sensing · 0 genes
• MARCH Ubiquitin Ligase · 0 genes
• Mast Cell Activation · 0 genes
• Mast Cell Activation · 0 genes
• Mast Cell Activation Signaling · 0 genes
• Mast Cell Immune Identity · 0 genes
• MHC-I Antigen Presentation · 0 genes
• MHC-II Antigen Presentation · 0 genes
• PD-L1 Checkpoint Program · 0 genes
• Purinergic Receptor Signaling · 0 genes
• RAS/MAPK Signaling · 0 genes
• RAS/Rho GTPase Signaling · 0 genes
• STAT5 Cytokine Signaling · 0 genes
• STAT6 IL-4 Signaling · 0 genes
• TGF-beta Repression · 0 genes
• TGF-beta Tolerance · 0 genes

Inflammation (18)

• Inflammasome Activation · 0 genes
• Inflammatory Activation · 0 genes
• Inflammatory IRAK3-BATF Response · 0 genes
• Inflammatory Mast Activation · 0 genes
• Innate Immune Stress · 0 genes
• MAPK-AP1 Signaling · 0 genes
• Mast Cell Activation · 0 genes
• NF-κB Activation · 0 genes
• NF-κB Activation · 0 genes
• NF-κB Immediate Response · 0 genes
• NF-κB Inflammatory Signaling · 0 genes
• NF-κB Signaling · 0 genes
• NF-κB Stress Signaling · 0 genes
• PI3K Inflammatory Signaling · 0 genes
• Pyroptosis Apoptosis Program · 0 genes
• Type I Interferon · 0 genes
• Type I Interferon · 0 genes
• Type I Interferon Response · 0 genes

Mast cell development (14)

• Mast Cell Identity · 0 genes
• Mast Cell Identity · 0 genes
• Mast Cell Identity · 0 genes
• Mast Cell Identity · 0 genes
• Mast Cell Identity · 0 genes
• Mast Cell Identity · 0 genes
• Mast Cell Progenitor · 0 genes
• Mast Cell Signaling · 0 genes
• Mast Cell Signaling · 0 genes
• Mast Cell Specification · 0 genes
• Mast Cell Transcription · 0 genes
• Myeloid Transcriptional Program · 0 genes
• NFAT Mast Cell Activation · 0 genes
• Tryptase Expression Mixed · 0 genes

migration & adhesion (5)

• Actin-driven Migration · 0 genes
• Cytoskeletal Adhesion Signaling · 0 genes
• Endosomal Autophagy Trafficking · 0 genes
• Integrin-Calcium Signaling · 0 genes
• Mast Cell Migration · 0 genes

Mitochondrial & OxPhos (8)

• Mitochondrial Fusion Stress · 0 genes
• Mitochondrial Maintenance · 0 genes
• Mitochondrial Metabolism Housekeeping · 0 genes
• Mitochondrial Organization · 0 genes
• Mitochondrial OxPhos · 0 genes
• Mitochondrial OxPhos · 0 genes
• Mitochondrial Respiratory Complex · 0 genes
• OxPhos & RNA Processing · 0 genes

Protein processing & ER (6)

• ER & Vesicle Trafficking · 0 genes
• ER Protein Quality Control · 0 genes
• ER Stress UPR · 0 genes
• Proteostasis & Translation · 0 genes
• UPR Secretory Stress · 0 genes
• Vesicle ER Trafficking · 0 genes

RNA processing & translation (18)

• Aminoacyl-tRNA Synthetases · 0 genes
• Co-transcriptional RNA Processing · 0 genes
• Mixed Splicing Stress · 0 genes
• mRNA Processing · 0 genes
• P-body mRNA Decay · 0 genes
• Post-transcriptional Regulation · 0 genes
• Post-transcriptional Regulation · 0 genes
• Pre-mRNA Splicing · 0 genes
• Proliferation RNA Processing · 0 genes
• RNA Decay Processing · 0 genes
• RNA Decay Regulation · 0 genes
• RNA Processing & Mitochondrial · 0 genes
• RNA Splicing · 0 genes
• RNA-binding Regulation · 0 genes
• Splicing & Transcription · 0 genes
• Transcription & Splicing · 0 genes
• Translation Initiation · 0 genes
• tRNA Aminoacylation · 0 genes

Stress (11)

• Autophagy Lysosomal Program · 0 genes
• Autophagy Stress Response · 0 genes
• ER-Mitochondria Homeostasis · 0 genes
• Glucocorticoid Stress Response · 0 genes
• Heat Shock Response · 0 genes
• Homeostatic Survival Signaling · 0 genes
• Hypoxia Stress Response · 0 genes
• Immediate Early Response · 0 genes
• Metabolic Redox Stress · 0 genes
• Oxidative Stress Response · 0 genes
• p38-MK2 Stress Signaling · 0 genes