DNA Damage Chromatin
Gene co-expression module in Mast cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes MYSM1 (histone H2A deubiquitinase, chromatin regulation), PRR14 (heterochromatin tethering protein), H2AX (histone H2A variant critical for DNA damage response/DSB signaling), INO80D (INO80 chromatin remodeling complex subunit), and ZMYM2 (LSD1/CoREST chromatin repressor complex) all point to chromatin regulation and DNA damage response. SRSF11 and SARNP are splicing factors. All disease deltas are zero. The module is small, low expression, and tightly centered on chromatin remodeling and DNA damage sensing, particularly the H2AX-centered DNA damage response.
Genes
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.