Myeloid Transcriptional Program
Gene co-expression module in Mast cells
| Category | Mast cell development |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 44 genes have a known function matching the annotation |
Why this annotation
This 44-gene module has low expression (~12% positive) and no disease association. Hub genes include ACER2 (alkaline ceramidase 2, sphingolipid metabolism, core), API5 (apoptosis inhibitor 5, anti-apoptotic, core), MZF1 (myeloid zinc finger 1, transcription factor for myeloid/mast cell genes, core), ELMO2 (engulfment and motility, phagocytosis/migration), NAA40 (N-terminal acetyltransferase), FAF1 (Fas-associated factor, apoptosis regulation), VPS8 (vacuolar protein sorting, endosomal trafficking), STARD5 (lipid transfer), CLCN6 (chloride channel). MZF1 is a known regulator of mast cell and myeloid gene expression. ACER2 links to ceramide/sphingolipid signaling. API5 and FAF1 relate to apoptosis regulation. The module is heterogeneous but has a thread of myeloid transcriptional regulation and lipid/apoptotic signaling.
Genes
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.