Glucocorticoid response
Gene co-expression module in Monocytes
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 14 genes have a known function matching the annotation |
Why this annotation
ZBTB16, KLF9, IL1R2, THBS1, HPGD, CCND3 and JDP2 are classic glucocorticoid-induced genes in monocytes. ZBTB16, KLF9 and IL1R2 are canonical GR targets, and THBS1 and HPGD fit an anti-inflammatory/resolving monocyte phenotype. This likely reflects steroid treatment or endogenous cortisol exposure in colon monocytes, and it contrasts with the inflammatory neighbor M7.
Genes
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.