Monocytes: gene co-expression modules

Circulating bone-marrow-derived phagocytes recruited rapidly to inflamed mucosa; they engulf pathogens, present antigen, release inflammatory mediators, then differentiate locally into macrophages or dendritic cells.

SCUBA's reference network for Monocytes holds 101 gene modules covering 1,113 genes. Each module is a group of genes that rise and fall together across these cells, annotated with the biological process it most likely represents.

View the Monocytes network in SCUBA

Antibacterial (1)

• BPI Antibacterial Response · 15 genes

Antiviral (5)

• IFN-gamma Response · 15 genes
• JAK-STAT IFN Signaling · 10 genes
• Type I Interferon · 10 genes
• Type I Interferon Response · 10 genes
• Type I Interferon Response · 9 genes

Cell contamination (1)

• Multi-lineage Contamination · 13 genes

Cell cycle (1)

• Mitotic Cell Cycle · 9 genes

Developmental (5)

• Granulocytic Differentiation · 11 genes
• Macrophage Differentiation · 12 genes
• Monocyte-DC Differentiation · 10 genes
• Monocyte-Macrophage Differentiation · 13 genes
• Myeloid Epigenetic Regulation · 10 genes

Housekeeping (3)

• Biosynthetic Metabolic Activation · 13 genes
• GIMAP activation · 11 genes
• Histone Chromatin Remodeling · 9 genes

Inflammatory (25)

• AP-1 Inflammatory Activation · 11 genes
• Classical Monocyte Activation · 10 genes
• Epigenetic Inflammatory Reprogramming · 9 genes
• Glucocorticoid Transcription · 8 genes
• IFN-gamma Monocyte Activation · 12 genes
• IFN-γ Monocyte Response · 11 genes
• IL-18 Inflammasome Response · 9 genes
• Immediate-Early Inflammatory · 12 genes
• Inflammatory Cell Death · 9 genes
• Inflammatory Metabolic Reprogramming · 9 genes
• Inflammatory Monocyte Activation · 14 genes
• Inflammatory Monocyte Activation · 9 genes
• Inflammatory Monocyte Activation · 8 genes
• Leukotriene-Alarmin Response · 9 genes
• Monocyte Activation State · 9 genes
• Monocyte Chemokine Secretion · 8 genes
• NF-κB Counter-regulation · 8 genes
• NF-κB Signaling · 13 genes
• NR4A Immediate-Early · 13 genes
• p38 MAPK Signaling · 14 genes
• SPP1+ Inflammatory Macrophage · 15 genes
• TNF-driven Activation · 12 genes
• TNF/IL-1 Cytokine Storm · 12 genes
• Tolerogenic Monocyte Activation · 10 genes
• Wnt/AP-1 Activation · 11 genes

Innate immunity (23)

• CCR2+ Monocyte Identity · 13 genes
• Complement C1q Macrophage · 13 genes
• Fc Receptor Activation · 9 genes
• FPR1 Innate Sensing · 10 genes
• IgA-Monocyte Activation · 12 genes
• Immunoproteasome Antigen Processing · 14 genes
• Inflammasome Activation · 13 genes
• Inflammasome Activation · 10 genes
• Innate Immune Transcription · 9 genes
• IRF1 Innate Activation · 9 genes
• M2 Macrophage Polarization · 16 genes
• Macrophage Innate Activation · 10 genes
• MHC II Antigen Presentation · 9 genes
• MHC-II Antigen Presentation · 10 genes
• Monocyte Identity · 9 genes
• Monocyte Innate Surveillance · 9 genes
• Myeloid Activation · 8 genes
• Myeloid Innate Receptor Signaling · 9 genes
• NLRP3 Inflammasome Activation · 12 genes
• Non-canonical NF-κB · 9 genes
• Non-classical Monocyte · 15 genes
• Pentose Phosphate Pathway · 13 genes
• TREM1 Inflammatory Signaling · 15 genes

Lysosomal & pahgocytosis (8)

• Autophagy Initiation · 10 genes
• Complement Receptor Activation · 10 genes
• Efferocytosis Tissue Macrophage · 9 genes
• Inflammatory Autophagy · 8 genes
• Monocyte Lipid Handling · 10 genes
• Non-classical Monocyte · 14 genes
• Tissue-destructive Macrophage · 16 genes
• Tissue-Resident Macrophage · 15 genes

Migration & adhesion (5)

• Classical Monocyte Trafficking · 13 genes
• G-protein Membrane Remodeling · 16 genes
• Integrin-mediated Migration · 16 genes
• Monocyte Tissue Infiltration · 12 genes
• Non-classical Monocyte Migration · 9 genes

Mitochondrial & OxPhos (1)

• Mitochondrial Immune Regulation · 8 genes

Stress (12)

• AMPK-FOXO Stress Response · 9 genes
• AP-1 Stress Response · 10 genes
• Autophagy Metabolic Stress · 10 genes
• Co-chaperone Proteostasis · 11 genes
• DNA Damage Response · 13 genes
• ER Stress Response · 12 genes
• ER Stress Response · 11 genes
• Heat Shock Response · 13 genes
• Immediate Early Activation · 12 genes
• Inflammatory Stress Response · 11 genes
• Integrated Stress Response · 8 genes
• Stress-Adapted Macrophage · 8 genes

Tissue adaptation (6)

• Glucocorticoid Response · 11 genes
• Hypoxia Response · 11 genes
• Monocyte Immune Tolerance · 10 genes
• Non-classical Monocyte State · 9 genes
• Tissue-Resident Macrophage · 12 genes
• Tissue-Resident Macrophage · 16 genes

Tissue homeostasis (3)

• M2 Macrophage Polarization · 9 genes
• MET Tissue Repair · 12 genes
• Tissue Macrophage Identity · 8 genes

Vesicular traficking (2)

• Endosomal Sorting · 10 genes
• Secretory Vesicle Trafficking · 10 genes