IgG Plasma Cells
Gene co-expression module in Plasma cells
| Category | IgG production |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 20 genes have a known function matching the annotation |
Why this annotation
IGHG1, IGHG2, IGHG3, IGHG4 are all IgG heavy chain constant region genes with extreme enrichment (11-50x) in igG_plasma cells. XBP1 is the master transcription factor for plasma cell differentiation and immunoglobulin secretion. ST6GAL1 mediates sialylation of IgG Fc, modulating effector function. CXCR4 mediates plasma cell homing to bone marrow niches. LTC4S and PECAM1 are enriched in igG_plasma. Module is strongly upregulated in inflammation in both UC and CD, consistent with IgG plasma cell expansion during active IBD. Neighbor to M64 (IgA) confirms isotype-specific immunoglobulin production context.
Genes
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.