Plasma cells: gene co-expression modules
Terminally differentiated B cells with expanded secretory machinery; in gut mucosa they secrete dimeric IgA transported into the lumen, neutralising microbes and shaping the microbiota.
SCUBA's reference network for Plasma cells holds 69 gene modules covering 1,272 genes. Each module is a group of genes that rise and fall together across these cells, annotated with the biological process it most likely represents.
View the Plasma cells network in SCUBA
Cell cycle (10)
- DNA Replication Fork · 0 genes
- Mitotic Entry G2/M · 0 genes
- Mitotic Spindle · 0 genes
- Nuclear Export Replication · 0 genes
- Plasmablast Proliferation · 0 genes
- Plasmablast Proliferation · 0 genes
- Plasmablast Proliferation · 0 genes
- Replication Checkpoint S/G2 · 0 genes
- S-phase DNA Replication · 0 genes
- Spindle Assembly Checkpoint · 0 genes
Cytoskeletal (2)
- Actin Cytoskeletal · 0 genes
- Actin Cytoskeletal Dynamics · 0 genes
DNA/chromatin regulation (4)
- Chromatin Remodeling · 0 genes
- DNA Damage Response · 0 genes
- Nuclear Transport Chromatin · 0 genes
- Plasmablast Differentiation · 0 genes
Housekeeping (1)
- Housekeeping Mixed · 0 genes
IgA production (3)
- IgA Plasma Cells · 0 genes
- Plasma Cell Differentiation · 0 genes
- Plasmablast Differentiation · 0 genes
IgG production (1)
- IgG Plasma Cells · 0 genes
Immune regulation (3)
- Glucocorticoid Response · 0 genes
- Innate Immune ISG · 0 genes
- Plasmablast MHC-II · 0 genes
Inflammation (1)
- Polyamine Biosynthesis · 0 genes
migration & adhesion (1)
- Plasmablast Trafficking · 0 genes
Mitochondrial & OxPhos (9)
- Glycolytic Reprogramming · 0 genes
- Mitochondrial Biogenesis · 0 genes
- Mitochondrial Biogenesis · 0 genes
- Mitochondrial OxPhos · 0 genes
- Mitochondrial Respiration · 0 genes
- Oxidative Phosphorylation · 0 genes
- Oxidative Phosphorylation · 0 genes
- Oxidative Phosphorylation · 0 genes
- OxPhos & Proteasome · 0 genes
Protein processing & ER (15)
- Chaperonin Protein Folding · 0 genes
- COPI Vesicle Trafficking · 0 genes
- ER Protein Folding · 0 genes
- ER Protein Folding · 0 genes
- ER Protein Processing · 0 genes
- ER Secretory Expansion · 0 genes
- ER Stress UPR · 0 genes
- ER Stress UPR · 0 genes
- ER Translocon Complex · 0 genes
- ER-Golgi Secretory Pathway · 0 genes
- N-glycosylation ER · 0 genes
- Proteasome Activity · 0 genes
- Protein Quality Control · 0 genes
- Ubiquitin-like Modification · 0 genes
- Unfolded Protein Response · 0 genes
RNA processing & translation (9)
- hnRNP RNA Processing · 0 genes
- Pre-mRNA Splicing · 0 genes
- Ribosome Biogenesis · 0 genes
- Ribosome Biogenesis · 0 genes
- Ribosome Biogenesis · 0 genes
- RNA Splicing & Glycolysis · 0 genes
- RNA Splicing Processing · 0 genes
- Spliceosome snRNP Assembly · 0 genes
- Translation Initiation · 0 genes
Stress (8)
- AP-1 Immediate Early · 0 genes
- Chaperone Proteostasis · 0 genes
- Heat Shock Response · 0 genes
- Immediate Early TFs · 0 genes
- Oxidative Stress Response · 0 genes
- Plasmablast Apoptosis · 0 genes
- Plasmablast Stress Activation · 0 genes
- Stress-induced Quiescence · 0 genes
Tissue residency (2)
- IgA Plasma Maturation · 0 genes
- Tissue Residency Activation · 0 genes