Pre-tuft Differentiation
Gene co-expression module in Tuft cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
This module is strongly enriched in pre_tuft cells (up to 11.9x). Hub genes COTL1 (coactosin-like actin-binding), ARPC3 (Arp2/3 actin nucleation complex), and GDI2 (Rho GDI cytoskeletal regulator) indicate actin cytoskeletal remodeling. CIB1 links calcium signaling to cytoskeletal dynamics. DMBT1 and LGALS2 suggest mucosal innate defense functions. The overall program reflects cytoskeletal reorganization and early differentiation events in pre-tuft cells transitioning toward mature tuft identity.
Genes
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.