SCUBA

Tuft cells: gene co-expression modules

Rare chemosensory epithelial cells with apical microvillar tufts; using taste-receptor signalling they detect helminths and protists, releasing IL-25 to launch type 2 immunity.

SCUBA's reference network for Tuft cells holds 87 gene modules covering 1,014 genes. Each module is a group of genes that rise and fall together across these cells, annotated with the biological process it most likely represents.

View the Tuft cells network in SCUBA

Antiviral (1)

Type I Interferon · 0 genes

Cehmical sensing (11)

Cholinergic Tuft Signaling · 0 genes
Cobalamin Uptake Program · 0 genes
Lipid Metabolite Transport · 0 genes
Prostaglandin Biosynthesis · 0 genes
Tuft Calcium Signaling · 0 genes
Tuft Cell Identity · 0 genes
Tuft Chemosensory Receptor · 0 genes
Tuft Chemosensory Signaling · 0 genes
Tuft Chemosensory Transduction · 0 genes
Tuft GPCR Signaling · 0 genes
Tuft PI3K-Src Signaling · 0 genes

Cell cycle (5)

chromatin regulation & transcription (3)

AP-1 Immediate Early · 0 genes
MYC-driven Biosynthesis · 0 genes
Transcription Elongation Control · 0 genes

Cytoskeletal (5)

Actin Cytoskeletal Remodeling · 0 genes
Pre-tuft Differentiation · 0 genes
Septin Cytoskeletal Organization · 0 genes
Tuft Cytoskeletal Remodeling · 0 genes
Tuft Microvilli Identity · 0 genes

Epithelial development (7)

Epithelial Progenitor Differentiation · 0 genes
Intestinal Progenitor Differentiation · 0 genes
Pre-tuft Differentiation · 0 genes
Pre-tuft Progenitor State · 0 genes
Tuft Cell Identity · 0 genes
Tuft Cell Identity · 0 genes
Tuft Progenitor State · 0 genes

Housekeeping (3)

Iron Homeostasis Housekeeping · 0 genes
Pre-tuft Biosynthetic · 0 genes
Progenitor Metabolic Reprogramming · 0 genes

Inflamation (7)

Antimicrobial Defense · 0 genes
Chemokine Secretion Program · 0 genes
EGF Ligand Inflammatory · 0 genes
Eicosanoid Inflammatory Modulation · 0 genes
IFN-Tuft Activation · 0 genes
Innate Immune Sensing · 0 genes
MHC II Antigen Presentation · 0 genes

migration & adhesion (1)

Tuft Surface Identity · 0 genes

Mitochondrial & OxPhos (19)

ATP Synthase OxPhos · 0 genes
Complex I Antioxidant OxPhos · 0 genes
Electron Transport Chain · 0 genes
Glycolytic TCA Metabolism · 0 genes
Mitochondrial Biogenesis · 0 genes
Mitochondrial Biogenesis · 0 genes
Mitochondrial Housekeeping · 0 genes
Mitochondrial OxPhos Assembly · 0 genes
Mitochondrial OxPhos Complex I · 0 genes
Mitochondrial OxPhos/TCA · 0 genes
Mitochondrial Proteostasis · 0 genes
Mitochondrial Translation · 0 genes
Mixed OxPhos Secretory · 0 genes
OxPhos Pre-tuft · 0 genes
Pre-tuft Metabolic Identity · 0 genes
Pre-tuft Mitochondrial Metabolic · 0 genes
Pre-tuft Progenitor Metabolism · 0 genes
Respiratory Chain Complex I · 0 genes
Respiratory Chain OxPhos · 0 genes

Protein processing & ER (5)

Chaperone-mediated Proteostasis · 0 genes
ER Membrane Biogenesis · 0 genes
ER Vesicle Trafficking · 0 genes
Proteasome Assembly · 0 genes
Protein Folding Proteostasis · 0 genes

RNA processing & translation (7)

Secretion (4)

Proliferating Mucus Secretory · 0 genes
Secretory Progenitor Commitment · 0 genes
Tuft Lipid Secretion · 0 genes
Tuft Secretory Processing · 0 genes

Stress (7)

Heat Shock Response · 0 genes
Heat Shock Stress Response · 0 genes
Immediate Early Stress · 0 genes
Metallothionein Stress Response · 0 genes
Oxidative Stress Response · 0 genes
Stress Transcriptional Response · 0 genes
Sulfur Redox Detox · 0 genes

WNT pathway (2)

Pre-tuft WNT Secretion · 0 genes
WNT Progenitor State · 0 genes