BRAP — BRCA1 associated protein
BRAP belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BRAP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | mRNA Decay Regulation RNA processing & translation | BAG5, BAP1, CEP120, HAUS3, IKZF5, MVD, NARF, PATL1 +9 more |
About the gene
| Synonyms | BRAP2, IMP, RNF52 |
|---|---|
| Chromosome | 12: 111642146-111685956 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Enzymes, Essential proteins, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins |
| Molecular function | Transferase |
| Biological process | Ubl conjugation pathway |
Function
Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.