mRNA Decay Regulation
Gene co-expression module in Gamma-delta T cells
| Category | RNA processing & translation |
|---|---|
| Genes | 18 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 18 genes have a known function matching the annotation |
Why this annotation
PATL1 is a key component of mRNA decapping and P-body assembly (mRNA decay). TWF1 (twinfilin) regulates actin filament dynamics by capping and sequestering actin monomers. SUGP2 and RBM15 are splicing/RNA-binding factors. RAF1 activates MAPK/ERK signaling. BAP1 is a deubiquitinase with tumor suppressor activity. IKZF5 (Pegasus) is an Ikaros family zinc finger transcription factor expressed in lymphocytes. TIGAR modulates glycolysis and apoptosis. CEP120 is involved in centriole elongation. The module is moderate coherence with several weak-membership hub genes, indicating a mixed program. The strongest coherent theme is post-transcriptional mRNA regulation combined with actin dynamics.
Genes
BAG5, BAP1, BRAP, CEP120, HAUS3, IKZF5, MVD, NARF, PATL1, PIGT, POLDIP3, RAF1, RAMAC, RBM15, SUGP2, TIGAR, TWF1, YY1AP1
Most correlated modules
- Hypoxia Stress Response · correlation 0.92
- Transcription-RNA Coupling · correlation 0.89
- Transcriptional Coactivation · correlation 0.85
- Wnt-STAT3 Signaling · correlation 0.83
- Hippo Pathway Signaling · correlation 0.82
- T Cell Exhaustion · correlation 0.81
- DNA Damage Ubiquitin · correlation 0.79
- Mitochondrial RNA Processing · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.