CDH23 — Cadherin related 23
CDH23 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CDH23's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Quiescent Arterial EC Endothelial cell development | ABCG2, ANKRD50, CAMTA1, CTNNAL1, CYB5A, HLF, INMT, ITM2B +10 more | View in SCUBA |
| Monocytes | Non-classical Monocyte Innate immunity | CD79B, CDKN1C, CHST7, CKB, CYFIP2, KNDC1, LYPD2, NEURL1 +6 more | View in SCUBA |
About the gene
| Synonyms | CDHR23, DFNB12, USH1D |
|---|---|
| Chromosome | 10: 71396920-71815947 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins |
| Biological process | Cell adhesion, Hearing, Sensory transduction, Vision |
Function
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.