Endothelial: gene co-expression modules
Vascular lining cells forming the blood–tissue interface; they control perfusion, permeability, and coagulation, and display adhesion molecules that recruit circulating leukocytes into inflamed mucosa.
SCUBA's reference network for Endothelial holds 143 gene modules covering 2,287 genes. Each module is a group of genes that rise and fall together across these cells, annotated with the biological process it most likely represents.
View the Endothelial network in SCUBA
Cell contamination (3)
- Immune Cell Contamination · 11 genes
- Macrophage Contamination · 12 genes
- Myeloid Contamination · 29 genes
Cell cycle (5)
- DNA Replication · 20 genes
- Mitotic Cell Cycle · 12 genes
- Mitotic Spindle · 23 genes
- S-phase DNA Replication · 9 genes
- S-phase Proliferation · 20 genes
Chemotaxis (2)
- CXCL12 Angiogenic Chemotaxis · 24 genes
- Endothelial Chemokine Response · 23 genes
Cytoskeletal (11)
- Actin Cytoskeletal Remodeling · 12 genes
- Actin Cytoskeletal Remodeling · 17 genes
- Actin Cytoskeletal Remodeling · 14 genes
- Actin Vesicle Trafficking · 19 genes
- Actomyosin Contractility · 11 genes
- Actomyosin Contractility · 20 genes
- Cytoskeletal Scaffolding · 15 genes
- EC Cytoskeletal Scaffold · 11 genes
- Hippo-YAP Cytoskeletal · 13 genes
- Rho-Actin Remodeling · 18 genes
- WAVE Complex Cytoskeleton · 12 genes
DNA/chromatin regulation (3)
- Chromatin Cell Cycle · 8 genes
- DNA Damage Repair · 16 genes
- NF-kB Chromatin Regulation · 13 genes
ECM remodeling (8)
- Basement Membrane Assembly · 13 genes
- ECM Fibrotic Remodeling · 16 genes
- Inflammatory Angiogenesis · 16 genes
- Inflammatory EC Activation · 13 genes
- Inflammatory ECM Remodeling · 15 genes
- Inflammatory ECM Remodeling · 14 genes
- TGF-beta ECM Remodeling · 19 genes
- Wnt Angiogenic Remodeling · 14 genes
Endothelial cell development (37)
- Angiogenic Endothelial Identity · 23 genes
- Angiogenic Metabolic Adaptation · 11 genes
- Arterial EC Homeostasis · 19 genes
- Arterial EC Identity · 16 genes
- Arterial EC Identity · 11 genes
- Arterial EC Identity · 10 genes
- Arterial EC Identity · 15 genes
- Arterial EC Identity · 14 genes
- Capillary Endothelial Identity · 19 genes
- EC Barrier Integrity · 23 genes
- EC Quiescence Identity · 17 genes
- Endothelial Angiogenic Identity · 14 genes
- Endothelial Junction Identity · 22 genes
- Endothelial Membrane Transport · 18 genes
- Endothelial NO Activation · 17 genes
- Endothelial Quiescence · 16 genes
- Endothelial Quiescence · 16 genes
- Endothelial Quiescence Identity · 16 genes
- Glucocorticoid Response · 17 genes
- Hypoxia-IFN Endothelial · 17 genes
- Inflammatory Angiogenesis · 16 genes
- Notch Arterial Identity · 23 genes
- Notch Ligand Signaling · 9 genes
- Quiescent Arterial EC · 19 genes
- Quiescent EC Identity · 28 genes
- Quiescent EC Identity · 14 genes
- Vascular EC Identity · 22 genes
- Vascular Homeostasis · 14 genes
- Vascular Tone Regulation · 22 genes
- Vasoactive GPCR Signaling · 19 genes
- VEGF Tip Cell Signaling · 16 genes
- Venous EC Identity · 21 genes
- Venous EC Identity · 27 genes
- Venous EC Identity · 16 genes
- Venous EC Identity · 15 genes
- Venous Endothelial Identity · 20 genes
- Venous Endothelial Identity · 17 genes
Housekeeping (4)
- Glycolysis Activation · 17 genes
- Housekeeping Metabolic · 17 genes
- Nuclear Transport · 27 genes
- Nuclear Transport · 17 genes
Inflammation (30)
- Chronic Inflammatory Activation · 11 genes
- Coagulation Protease Signaling · 10 genes
- Complement Innate Immune · 18 genes
- EC Inflammatory Activation · 21 genes
- Glucocorticoid Response · 15 genes
- IFN-gamma Antigen Processing · 12 genes
- IFN-gamma Response · 27 genes
- IL-13/STAT6 Signaling · 27 genes
- IL-27 Receptor Signaling · 9 genes
- IL33 Alarmin Signaling · 10 genes
- Inflammatory Angiogenesis · 15 genes
- Inflammatory Angiogenic Activation · 13 genes
- Inflammatory EC Activation · 15 genes
- Inflammatory EC Activation · 12 genes
- Inflammatory Endothelial Activation · 17 genes
- Inflammatory Kinase Signaling · 16 genes
- Inflammatory Stress Response · 18 genes
- Inflammatory Stress Response · 20 genes
- Leukocyte Recruitment Signaling · 15 genes
- MHC Class I Presentation · 10 genes
- MHC Class II Presentation · 16 genes
- NF-κB Activation · 14 genes
- NF-κB Early Response · 12 genes
- NF-κB Endothelial Activation · 14 genes
- NF-κB Stress Signaling · 13 genes
- Procoagulant TGF-β Response · 16 genes
- SPP1 Inflammatory Activation · 18 genes
- Type I Interferon · 18 genes
- Type I Interferon Response · 12 genes
- Venular Inflammatory Activation · 17 genes
Metabolite transfer (2)
- Caveolae-mediated Transcytosis · 28 genes
- Inflammatory Lipid Metabolism · 14 genes
migration & adhesion (7)
- Endocytic Membrane Remodeling · 13 genes
- Endothelial Barrier Homeostasis · 20 genes
- Endothelial Cell Migration · 14 genes
- Endothelial Lipid Signaling · 12 genes
- Integrin-Actin Adhesion · 15 genes
- Vascular Barrier Integrity · 20 genes
- YAP Mechanotransduction · 16 genes
Mitochondrial & OxPhos (5)
- Mitochondrial Metabolic Stress · 12 genes
- Mitochondrial OxPhos · 12 genes
- Mitochondrial OxPhos · 18 genes
- Oxidative Phosphorylation · 19 genes
- Respiratory Chain Complex · 9 genes
Protein processing & ER (5)
- ER Protein Processing · 14 genes
- ER-Golgi Trafficking · 19 genes
- ER-Golgi Trafficking · 13 genes
- Proteasomal Degradation · 12 genes
- UPR / ER Stress · 19 genes
RNA processing & translation (5)
- mRNA Splicing · 17 genes
- mRNA Splicing Stress · 9 genes
- Spliceosome snRNP Assembly · 15 genes
- Stress RNA Processing · 14 genes
- Translation Elongation · 16 genes
Stress (16)
- ER Calcium Stress · 10 genes
- Heat Shock Response · 11 genes
- Hypoxia Response · 12 genes
- Hypoxia Stress Response · 16 genes
- Inflammatory Stress Response · 16 genes
- Integrated Stress Response · 12 genes
- Lipid Droplet Hypoxia · 8 genes
- Lysosomal Autophagy Program · 13 genes
- Mitochondrial Oxidative Stress · 14 genes
- Mitophagy Stress Response · 16 genes
- NF-κB Oxidative Stress · 22 genes
- Oxidative Stress Response · 20 genes
- p53 Stress Response · 10 genes
- Redox Stress Response · 16 genes
- Shear Stress Response · 20 genes
- TRAIL-mediated Apoptosis · 11 genes