GPR15LG — G protein-coupled receptor 15 ligand
GPR15LG belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GPR15LG's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Long-gene nuclear transcripts Technical artifact | CNTN4, GPR160, GRIA4, HSD11B2, OSBPL8, PCLO, PPP2R3A | View in SCUBA |
About the gene
| Synonyms | AP-57, C10orf99, CSBF, FLJ21763, GPR15L, RLLV1833, UNQ1833 |
|---|---|
| Chromosome | 10: 84173801-84185294 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Predicted secreted proteins |
| Molecular function | Antibiotic, Antimicrobial, Cytokine |
| Biological process | Chemotaxis |
Function
Highly cationic protein that has multiple functions. Acts as a chemotactic factor that mediates lymphocytes recruitment to epithelia through binding and activation of the G-protein coupled receptor GPR15. May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest. May regulate keratinocyte proliferation. In addition, through activation of Mas-related G protein-coupled receptors (MRGPRs) contributes to pruritogenesis by activating itch-selective sensory neurons and mast cells degranulation. Has antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Actinomyces spec. and Mycoplasma hominis and lentivirus
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.