Enterocytes: gene co-expression modules
Absorptive columnar epithelium of the small intestine; brush-border enzymes and transporters digest and absorb nutrients and bile acids, and lipids are packaged into chylomicrons for lymphatic export.
SCUBA's reference network for Enterocytes holds 101 gene modules covering 1,052 genes. Each module is a group of genes that rise and fall together across these cells, annotated with the biological process it most likely represents.
View the Enterocytes network in SCUBA
Absorption (18)
- Amino acid absorption · 8 genes
- Amino acid absorption · 11 genes
- Apical Na+/H+ transport · 8 genes
- Brush border lipid handling · 11 genes
- Brush-border enterocyte · 9 genes
- Brush-border nutrient uptake · 7 genes
- Brush-border Nutrient Uptake · 8 genes
- Colonocyte Solute Transport · 10 genes
- Crypt-top colonocyte · 9 genes
- Dietary lipid absorption · 12 genes
- Endocytic nutrient uptake · 8 genes
- Enterocyte Ion/Nutrient Transport · 11 genes
- Lipid/bile acid uptake · 11 genes
- Mature colonocyte absorptive · 18 genes
- Mature enterocyte differentiation · 14 genes
- Mature enterocyte transport · 10 genes
- Surface colonocyte transport · 13 genes
- Villus-tip enterocyte transport · 8 genes
Antibacterial (2)
- Crypt antimicrobial progenitor · 9 genes
- DUOX2 oxidative defense · 8 genes
Chromatin regulation & transcription (1)
- Colonocyte differentiation TFs · 16 genes
Cytoskeletal (5)
- Actin cytoskeleton · 9 genes
- Cortical actin junctions · 7 genes
- Epithelial polarity cytoskeleton · 12 genes
- Microvillus actin cytoskeleton · 7 genes
- Spectrin-actin scaffold · 11 genes
Epithelial development (10)
- Colonocyte differentiation signaling · 11 genes
- Colonocyte terminal differentiation · 11 genes
- EGFR wound response · 7 genes
- Enterocyte identity TFs · 9 genes
- KLF4 Terminal Differentiation · 9 genes
- Mature colonocyte brush-border · 11 genes
- SATB2 colonic identity · 8 genes
- Secretory progenitor Notch · 14 genes
- Surface colonocyte differentiation · 11 genes
- Transit-amplifying progenitor · 9 genes
Housekeeping (3)
- Abundant Transcript Baseline · 15 genes
- High-abundance housekeeping · 10 genes
- Lysosomal/ferritin housekeeping · 14 genes
Inflammation (9)
- Epithelial NF-kB response · 13 genes
- IFN-gamma immunoproteasome · 11 genes
- IFN-gamma response · 11 genes
- IFN-gamma STAT1 signaling · 10 genes
- Inflammatory cell death · 8 genes
- MHC antigen presentation · 16 genes
- NF-kB epithelial activation · 10 genes
- STAT3/JNK signaling · 9 genes
- TNF receptor signaling · 7 genes
Lipid metabolism (9)
- Chylomicron apolipoprotein assembly · 9 genes
- Chylomicron lipid absorption · 12 genes
- Enterocyte fatty-acid catabolism · 8 genes
- Enterocyte lipid metabolism · 12 genes
- Enterocyte lipid trafficking · 9 genes
- PGC1A/ERRG metabolic program · 15 genes
- PPARA/FXR fatty acid oxidation · 13 genes
- Sterol Transfer · 7 genes
- Surface colonocyte lipid-droplet · 13 genes
Migration & adhesion (9)
- Apical junction complex · 12 genes
- Apicobasal polarity · 8 genes
- Apicobasal polarity scaffold · 12 genes
- Basal adhesion remodeling · 11 genes
- Epithelial junction adhesion · 11 genes
- Epithelial junction polarity · 14 genes
- Focal adhesion actin · 13 genes
- Junctional Hippo/TGF-beta signaling · 9 genes
- YAP cytoskeletal remodeling · 14 genes
Mitochondrial & OxPhos (8)
- ATP Synthase OXPHOS · 8 genes
- Core energy metabolism · 9 genes
- Electron Transport Chain · 15 genes
- Mitochondrial Chaperonin · 7 genes
- Mitochondrial Energy Metabolism · 11 genes
- Oxidative Phosphorylation · 12 genes
- Respiratory Chain OXPHOS · 7 genes
- Respiratory Chain Subunits · 7 genes
Nutrient metabolism (4)
- Carbohydrate Digestion/Detox · 10 genes
- Gluconeogenesis/fructose metabolism · 11 genes
- Mature colonocyte metabolism · 15 genes
- Xenobiotic Detoxification · 10 genes
Protein processing & ER (2)
- ER chaperone/UPR · 12 genes
- ER-autophagy homeostasis · 10 genes
RNA processing & translation (3)
- Nucleolar RNA-binding · 11 genes
- Translation Elongation · 14 genes
- Translational repression · 8 genes
Secretion (2)
- Crypt CFTR secretion · 10 genes
- Serotonergic receptor signaling · 7 genes
Stress (5)
- Inflammatory hypoxic response · 8 genes
- JUN stress response · 8 genes
- Metallothionein metal response · 10 genes
- Redox Detoxification · 12 genes
- Stress-responsive transcription · 7 genes
Technical artifact (11)
- Long-gene intronic signal · 14 genes
- Long-gene Nuclear Transcripts · 12 genes
- Long-gene Nuclear Transcripts · 15 genes
- Long-gene nuclear transcripts · 15 genes
- Long-gene nuclear transcripts · 8 genes
- Long-gene nuclear transcripts · 9 genes
- Long-gene nuclear transcripts · 7 genes
- Long-gene nuclear transcripts · 8 genes
- Long-gene nuclear transcripts · 12 genes
- Long-gene transcript bias · 7 genes
- Long-gene transcript bias · 8 genes