HSD3B2 — Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
HSD3B2 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HSD3B2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Colonocyte Solute Transport Nutrient processing | ATP8A1, B3GNT6, BMF, BTBD3, ERBB2, ETNK1, FAM3B, FGFR2 +15 more | View in SCUBA |
About the gene
| Synonyms | SDR11E2 |
|---|---|
| Chromosome | 1: 119414931-119423035 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Isomerase, Multifunctional enzyme, Oxidoreductase |
| Biological process | Lipid metabolism, Steroidogenesis |
Function
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.