Colonocyte Solute Transport
Gene co-expression module in Colonocytes
| Category | Absorption |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 24 genes have a known function matching the annotation |
Why this annotation
SLC14A2 (urea transporter, 19.5x sen_colono), SLC51A (OSTalpha bile acid transporter, 12.4x), MEP1B (brush border meprin B, 11.3x), and HSD3B2 (steroid metabolism, 13.5x) are the most enriched sen_colono genes. ATP8A1 is a phospholipid flippase maintaining membrane asymmetry. B3GNT6 participates in O-glycan/mucin core synthesis. SLC22A5 (OCTN2) transports carnitine. BMF and GULP1 suggest apoptotic priming. FGFR2 and PROM1 add progenitor/differentiation context. The module is mixed but centers on colonocyte-specific solute transport (urea, bile acids, carnitine) with differentiation signals.
Genes
Most correlated modules
- Lipid Xenobiotic Metabolism · correlation 0.80
- Brush Border Cytoskeleton · correlation 0.77
- Mature Colonocyte Identity · correlation 0.76
- Mature Colonocyte Metabolism · correlation 0.59
- Colonocyte Water Transport · correlation 0.59
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.