ATP8A1 — ATPase phospholipid transporting 8A1
ATP8A1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ATP8A1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Mature colonocyte brush-border Epithelial development | AGMO, CA3, CNKSR3, COBL, EMB, EPB41L3, NGEF, PAG1 +2 more | View in SCUBA |
| Fibroblasts | Intestinal Fibroblast Identity Developmental | ABR, AFF3, ATP9A, CAMK4, DSE, ENPP2, GLP2R, MRPS6 +7 more | View in SCUBA |
| Gamma-delta T cells | TCR Threshold Regulation TCR Signaling | AGO2, AUTS2, CMIP, CNOT6L, CSNK1D, FOXO1, GSPT1, MAP3K8 +8 more | |
| Mucosal-associated invariant T cell | SWI/SNF Chromatin Remodeling DNA/chromatin regulation | ABTB3, AOAH, ARID1B, ARID2, ATXN1, BRAF, CCSER2, CDC42SE2 +13 more | |
| Neutrophils | Myeloid Lipid Remodeling Developmental | ADK, AGPS, ATP8B4, CLTCL1, DOP1B, ERG, GPD2, HNRNPLL +3 more |
About the gene
| Synonyms | ATPIA |
|---|---|
| Chromosome | 4: 42408373-42657121 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Translocase |
| Biological process | Lipid transport, Transport |
Function
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase- mediated translocation of phosphatidylethanolamine (PE) at the cell membrane (By similarity). Acts as aminophospholipid translocase at the cell membrane in neuronal cells (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.