HTRA3 — HtrA serine peptidase 3
HTRA3 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HTRA3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | TGF-beta ECM Regulation ECM production | FIBIN, GAS7, GLT8D2, ISLR, LTBP2, OAF, SNED1, SPON2 | View in SCUBA |
About the gene
| Synonyms | Prsp, Tasp |
|---|---|
| Chromosome | 4: 8269754-8307098 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Enzymes, Predicted secreted proteins |
| Molecular function | Hydrolase, Protease, Serine protease |
Function
Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF- beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.