SPON2 — Spondin 2

SPON2 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

SPON2's module in each cell type

Cell type	Module	Shares the module with
Fibroblasts	TGF-beta ECM Regulation ECM production	FIBIN, GAS7, GLT8D2, HTRA3, ISLR, LTBP2, OAF, SNED1	View in SCUBA
Gamma-delta T cells	Cytotoxic Effector Program cytotoxicity	ADGRG1, ANXA4, CADM1, CX3CR1, FCGR3A, FGFBP2, FGL2, GNLY +14 more
Innate lymphoid cells	ILC3 identity Differentiation	ABCC1, BCL6, CCND3, CELF2, CHKB, DNAAF2, ENSG00000285976, EREG +31 more	View in SCUBA
Mucosal-associated invariant T cell	Innate Stress Activation Stress	BATF, BCL2L1, BRD8, DNAJA3, FAM13A, IL6ST, LRRN3, OXNAD1 +5 more
Natural Killer cells	Cytotoxic NK Maturation Cytotoxicity	ADGRG1, AKR1C3, CXCR2, FCGR3A, FGFBP2, GK5, LGR6, MTSS1 +4 more	View in SCUBA
Pericytes	Fibrotic ECM Remodeling ECM remodeling	ADAMTS12, ADAMTS2, CD248, COL12A1, COL5A2, FSTL1, LOXL2, NID2 +2 more	View in SCUBA

About the gene

Synonyms	DIL1
Chromosome	4: 1166932-1208962
Predicted location	Intracellular, Secreted
Essential gene	No
Protein class	Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Biological process	Cell adhesion, Immunity, Innate immunity

Function

Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.