TGF-beta ECM Regulation
Gene co-expression module in Fibroblasts
| Category | ECM production |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
LTBP2 (latent TGF-β binding protein 2) sequesters TGF-β in the ECM and regulates its bioavailability. HTRA3 is a serine protease that cleaves LTBP and modulates TGF-β signaling. SPON2 (spondin-2/mindin) is an ECM protein involved in integrin-mediated signaling. ISLR (immunoglobulin superfamily containing leucine-rich repeat) is a marker of subepithelial/lamina propria fibroblasts and modulates Wnt/TGF-β signaling. SNED1 is an ECM glycoprotein. FIBIN is a secreted factor expressed in mesenchymal cells. The strong CD-specific inflammation signal and deep remission reversal suggest a CD-enriched activated fibroblast ECM program, with TGF-β regulation as a central theme. Moderate coherence reflects some heterogeneity.
Genes
FIBIN, GAS7, GLT8D2, HTRA3, ISLR, LTBP2, OAF, SNED1, SPON2
Most correlated modules
- BMP-ECM Fibroblast · correlation 0.66
- Stromal Fibroblast Activation · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.