NTRK3 — Neurotrophic receptor tyrosine kinase 3
NTRK3 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NTRK3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Tfh CXCL13 program B cell help | ASCL2, C11orf96, CD8B2, CXCL13, CXXC5, FILIP1L, FZD3, GFOD1 +5 more | View in SCUBA |
| Fibroblasts | Retinoid Stromal Quiescence Developmental | ACAN, GALNT17, KCTD8, NDUFA4L2, PCDH17, PDE8B, RBP4, RXRG +5 more | View in SCUBA |
About the gene
| Synonyms | TRKC |
|---|---|
| Chromosome | 15: 87859751-88256791 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase |
| Biological process | Differentiation, Neurogenesis |
Function
Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.