RXRG — Retinoid X receptor gamma
RXRG belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RXRG's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Retinoid Stromal Quiescence Developmental | ACAN, GALNT17, KCTD8, NDUFA4L2, NTRK3, PCDH17, PDE8B, RBP4 +5 more | View in SCUBA |
About the gene
| Synonyms | NR2B3, RXR-gamma, RXRgamma |
|---|---|
| Chromosome | 1: 165400922-165445355 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, FDA approved drug targets, Nuclear receptors, Plasma proteins, Predicted intracellular proteins, Transcription factors |
| Molecular function | DNA-binding, Receptor |
| Biological process | Transcription, Transcription regulation |
Function
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.