OARD1 — O-acyl-ADP-ribose deacylase 1
OARD1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
OARD1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Chromatin Architecture DNA/chromatin regulation | CBFB, CCDC137, CTCF, DCAF15, GMCL1, HNRNPUL2, HP1BP3, KDM4A +9 more |
About the gene
| Synonyms | C6orf130, dJ34B21.3, MGC19570, TARG1 |
|---|---|
| Chromosome | 6: 41033627-41097787 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase |
Function
ADP-ribose glycohydrolase that hydrolyzes ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on glutamate and O-acetyl-ADP-D-ribose. Specifically acts as a glutamate mono-ADP- ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to glutamate residues on proteins. Does not act on poly-ADP-ribosylated proteins: the poly-ADP-ribose chain of poly-ADP-ribosylated glutamate residues must by hydrolyzed into mono-ADP-ribosylated glutamate by PARG to become a substrate for OARD1. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Catalyzes the deacylation of O-acetyl-ADP-ribose, O-propionyl-ADP-ribose and O- butyryl-ADP-ribose, yielding ADP-ribose plus acetate, propionate and butyrate, respectively.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.