HP1BP3 — Heterochromatin protein 1 binding protein 3
HP1BP3 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HP1BP3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Chromatin Regulation DNA/chromatin regulation | ADI1, ASXL2, BTG3, CASP8, CHD3, CTSS, CWF19L2, DENND2D +17 more | View in SCUBA |
| CD8⁺ T cells | S-phase Chromatin Replication Cell cycle | ANP32E, BRCA2, CKAP2, HDGF, LBR, MIS18BP1, NSD2, NUCKS1 +4 more | View in SCUBA |
| Gamma-delta T cells | Chromatin Architecture DNA/chromatin regulation | CBFB, CCDC137, CTCF, DCAF15, GMCL1, HNRNPUL2, KDM4A, NFATC2IP +9 more | |
| Innate lymphoid cells | Actin Cytoskeleton Dynamics Cytoskeleton & motility | ACTN4, ALDH9A1, APBB1IP, ARHGAP10, CDC37, CXXC5, FAM136A, FERMT3 +26 more | View in SCUBA |
| Macrophages | RNA Splicing Processing Housekeeping | ARMCX3, CIRBP, ELK4, GATAD1, H3-3B, HNRNPA2B1, HNRNPA3, HNRNPL +13 more | View in SCUBA |
| Mucosal-associated invariant T cell | Integrin Actin Adhesion migration & adhesion | ACTR2, ANKRD10, ATP2B1, DDX46, HPS3, JAK1, LINS1, LRIF1 +11 more | |
| Neutrophils | Mitotic Spindle Cell cycle | ANP32B, ANP32E, DEK, H2AZ2, H4C3, HMGB1, HNRNPH1, NUCKS1 +4 more |
About the gene
| Synonyms | HP1-BP74 |
|---|---|
| Chromosome | 1: 20740266-20787323 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | DNA-binding |
Function
Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity. Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo- resistance and self-renewal
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.