PRSS8 — Serine protease 8
PRSS8 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PRSS8's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Senescent Cell Death Senescence & shedding | ARSA, CDKN1A, CLSTN1, COL17A1, DNAJC5, GPR35, HSPG2, JUP +11 more | View in SCUBA |
About the gene
| Synonyms | CAP1 |
|---|---|
| Chromosome | 16: 31131433-31135727 |
| Predicted location | Membrane, Secreted |
| Essential gene | No |
| Protein class | Enzymes, Predicted membrane proteins, Predicted secreted proteins |
| Molecular function | Hydrolase, Protease, Serine protease |
Function
Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.