Senescent Cell Death
Gene co-expression module in Colonocytes
| Category | Senescence & shedding |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 20 genes have a known function matching the annotation |
Why this annotation
CDKN1A (p21/CIP1, canonical CDK inhibitor and senescence effector) is a defining senescence marker. RIPK3 (necroptosis kinase), SMPD1 (acid sphingomyelinase, lysosomal stress/ceramide), TNIP1 (TNFAIP3-interacting protein, NF-κB modulator), PSAP (prosaposin, lysosomal), ARSA (arylsulfatase A, lysosomal), SEMA3B (semaphorin, repulsive guidance/apoptosis), COL17A1 (collagen XVII, hemidesmosome/shedding), SELENOP (selenoprotein P, oxidative stress protection), PRSS8 (prostasin, serine protease shed from surface), HSPG2 (perlecan, ECM). The combination of p21, necroptosis, lysosomal enzymes, and surface protease shedding strongly supports a senescent colonocyte program with cell death priming.
Genes
Most correlated modules
- Senescent Surface Identity · correlation 0.94
- TNF Apoptosis Resistance · correlation 0.93
- Colonocyte Cytoskeletal Contractility · correlation 0.92
- Senescent Stress Signaling · correlation 0.92
- Senescent Colonocyte Differentiation · correlation 0.91
- Junction Cytoskeletal Remodeling · correlation 0.90
- Epithelial Junction Integrity · correlation 0.90
- ESCRT Membrane Remodeling · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.