JUP — Junction plakoglobin
JUP belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
JUP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory EC Activation Inflammation | ANGPT2, B3GNT5, BAIAP2, EPHA2, GMFB, HIC1, HMOX1, LPIN2 +6 more | View in SCUBA |
| Lymphatic endothelial | Anticoagulant Barrier endothelial development | AP2A2, ERICH1, KBTBD11, MMRN1, MYCT1, PARD6G, TFPI, TIMP3 | View in SCUBA |
| Pericytes | Cytoskeletal Remodeling Cytoskeletal | ARHGAP18, F2RL3, FSCN1, IVNS1ABP, PASK, SEMA3F, TBCD, VWA1 | View in SCUBA |
About the gene
| Synonyms | CTNNG, DP3, DPIII, PDGB, PG, PKGB |
|---|---|
| Chromosome | 17: 41754604-41786931 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Biological process | Cell adhesion |
Function
Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.