SAP30L — SAP30 like
SAP30L belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SAP30L's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | RNA Splicing Processing RNA processing & translation | ABCF2, ACTR1B, ARF3, C1orf35, CDK11B, DCAF8, DDX39B, EIF4EBP2 +16 more |
About the gene
| Synonyms | FLJ11526, NS4ATP2 |
|---|---|
| Chromosome | 5: 154445997-154461053 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | DNA-binding, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Functions as a transcription repressor, probably via its interaction with histone deacetylase complexes. Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus. Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA. Binds phosphoinositol phosphates (phosphoinositol 3- phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import. Functions as a transcription repressor; isoform 2 has lower transcription repressor activity than isoform 1 and isoform 3. Functions as a transcription repressor; its activity is marginally lower than that of isoform 1
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.