RNA Splicing Processing
Gene co-expression module in Gamma-delta T cells
| Category | RNA processing & translation |
|---|---|
| Genes | 25 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 25 genes have a known function matching the annotation |
Why this annotation
This module has moderate coherence with mixed membership scores. Hub genes include PPP6R1 (PP6 phosphatase, DNA damage response/splicing), DDX39B (RNA helicase/mRNA export), UBE2Z (ubiquitin conjugating enzyme), RABL6 (Rab-like GTPase, cell cycle/MDM2 regulation), EIF4EBP2 (translation repressor), SET (PP2A inhibitor/chromatin), KHDRBS1 (Sam68, RNA-binding/splicing), SPATA13 (actin dynamics), PNKP (DNA repair), POLR2J3-1 (RNA pol II), PSIP1 (LEDGF/chromatin/splicing), WRNIP1 (DNA replication stress), ACTR1B (actin/dynactin), SF3A2 (splicing), ABCF2 (ABC transporter), SNRNP70 (splicing). The preponderance of RNA splicing (DDX39B, KHDRBS1, SF3A2, SNRNP70, POLR2J3-1), mRNA processing, and DNA repair genes, combined with moderate coherence, suggests a mixed RNA processing and DNA repair/genome maintenance module. The dominant program is RNA processing/splicing.
Genes
ABCF2, ACTR1B, ARF3, C1orf35, CDK11B, DCAF8, DDX39B, EIF4EBP2, IDH3B, KHDRBS1, MTDH, PNKP, POLR2J3-1, PPP6R1, PSIP1, RABL6, RSAD1, SAP30L, SET, SF3A2, SNRNP70, SPATA13, UBE2Z, WRNIP1, YY1
Most correlated modules
- Chromatin Architecture · correlation 0.88
- ER Protein Biogenesis · correlation 0.87
- Basal Cell Maintenance · correlation 0.82
- Mitochondrial Biogenesis · correlation 0.81
- RNA Processing · correlation 0.81
- SR Kinase & RNA · correlation 0.80
- T Cell Maturation · correlation 0.78
- mRNA Splicing · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.