AKT survival signaling
Gene co-expression module in CD4⁺ T cells
| Category | TCR/AP1/NFKb pathway |
|---|---|
| Genes | 19 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 19 genes have a known function matching the annotation |
Why this annotation
Hub AKT1 (survival/signaling), ATF7 (AP-1 family TF), XIAP (apoptosis inhibitor), PTPN6/SHP-1 (TCR negative regulator), CHD8/NIPBL/TOP2B (chromatin), ATP6AP1/RUBCN (autophagy/lysosomal), and ubiquitin (UBR2, IP6K2). This is a heterogeneous signaling/survival module anchored on AKT1-XIAP-PTPN6 with AP-1 component ATF7, consistent with T-cell activation/survival signaling rising with inflammation. Best captured as a TCR/AP1/signaling module.
Genes
ABHD2, AKT1, ARL14EP, ATF7, ATP6AP1, CHD8, GNGT2, IP6K2, ITSN2, KRTCAP2, MRFAP1L1, NIPBL, PRRC2A, PTPN6, RUBCN, SNX14, TOP2B, UBR2, XIAP
Most correlated modules
- CCR5 effector migration · correlation 0.91
- Protein/ER secretory machinery · correlation 0.80
- mRNA Splicing Processing · correlation 0.72
- Vesicle Trafficking Signaling · correlation 0.71
- Chromatin transcription regulation · correlation 0.70
- Glycosylation & trafficking · correlation 0.66
- Leukocyte Motility · correlation 0.66
- Activated Effector ISG · correlation 0.63
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.