Interferon-stimulated genes
Gene co-expression module in CD4⁺ T cells
| Category | Anti-viral |
|---|---|
| Genes | 23 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 23 genes have a known function matching the annotation |
Why this annotation
Top hubs (FKBP8, ARPC5L, WDR1, PSMA5, ARPC4) are housekeeping/cytoskeletal genes, but the module also contains a clear set of interferon-stimulated/antiviral genes: BST2 (tetherin), IFI27L2, IFI35, APOBEC3G. These ISGs are upregulated in inflammation (positive delta_inflammation in both UC and CD, reversed with treatment), pointing to a type I IFN antiviral response component. The interferon genes are strong-membership hubs and drive the disease association, so an antiviral interpretation best captures the disease-relevant signal despite mixed housekeeping content.
Genes
APOBEC3G, ARPC4, ARPC5L, BAK1, BST2, DCTN3, ECH1, ETFB, FAM104A, FBXW5, FKBP8, GSTO1, IFI27L2, IFI35, LSM2, MAP2K2, MTCH2, NUDT5, POLR2G, PSMA5, SF3B5, VPS28, WDR1
Most correlated modules
- Mitochondrial OxPhos · correlation 0.95
- Proteasome translation · correlation 0.91
- ER protein processing · correlation 0.90
- Actin cytoskeleton · correlation 0.89
- Proteostasis OxPhos · correlation 0.88
- Actomyosin signaling · correlation 0.87
- Activated effector Tcell · correlation 0.85
- Oxidative Phosphorylation · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.