Type I Interferon
Gene co-expression module in Colorectal carcinoma
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 11 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes MX1, IFI6, ISG15, BST2, PLSCR1, IFI27, LY6E, OAS1, STAT1, IFITM3 are all canonical interferon-stimulated genes (ISGs), predominantly induced by Type I interferons (IFN-α/β). MX1, OAS1, ISG15, IFI6, IFI27, LY6E, BST2, PLSCR1, and IFITM3 are well-established ISG hallmarks. STAT1 is the primary transcription factor downstream of IFN signaling. SPATS2L is also an ISG. This is a textbook Type I IFN response module. Its neighborhood co-occurrence with M80 (IFN-γ/antigen presentation) is consistent with a shared interferon-rich tumor microenvironment.
Genes
Most correlated modules
- IFN-γ Antigen Presentation · correlation 0.67
- Acute Phase Inflammatory · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.